The MMT 100 starts just below the Massanutten Mountain's northeastern ridge, which overlooks the south fork of the Shenandoah River. After running the eastern Massanutten Trail and connecting trails, the MMT 100 crosses the Crisman Hollow Road and ascends the Jawbone Gap Trail to the Massanutten Trail on Kerns Mountain. The course then gets back to the Crisman Hollow Road again and takes it south to the Visitors Center. It then goes south on the Massanutten Mountain South Trail to the Bird Knob Trail and then loops back to the Picnic Area and the crossing of Route 211. Runners then take the Massanutten Connector Trail to Scothorn Gap where it goes down the hill to the Crisman Hollow Road to Gap Creek, then up Jawbone Gap again, and eventually up the western Massanutten Trail before returning to the Skyline Ranch Resort.